However, resveratrol is difficult to be absorbed by the gut, and the little resveratrol that ends up in the body is broken down very quickly. Resveratrol is needed to activate the sirtuin genes (which protect our DNA and epigenome), while NMN is needed to fuel the sirtuins. Studies have shown that resveratrol can reduce the risk of heart disease, cancer, and neurodegeneration.ĭavid Sinclair believes that resveratrol works synergistically with NMN. Resveratrol is a stilbenoid found in the skin of grapes in low amounts. Our view: We are lukewarm about resveratrol. TMG (trimethylglycine or betaine): 500 mg to 1,000 mg per dayĢ.Quercetin and fisetin: 500 mg each, once per day, in the morning.Spermidine: 1 mg per day, in the morning.Coenzyme Q10 (coQ10): recent status unknown.Alpha lipoic acid (ALA): recent status unknown. Vitamin K2: ideally 180 to 360 micrograms per day.Vitamin D3: ideally 4,000 to 5,000 IU per day.Resveratrol: 1g per day, in the morning.Nicotinamide mononucleotide (NMN): 1g per day, in the morning.Sinclair’s supplement and longevity drug stack likely looks as follows: We don’t know if he still takes these supplements or whether he takes additional supplements that are not included on this list.įor example, in his book Lifespan, he mentions on page 304 that he takes NMN and resveratrol every morning, often mixed in his yogurt.īased on multiple, recent interviews and his book, Dr. We compiled this list from interviews and books in which Dr. Sinclair has made a point to not promote or endorse any supplement products. You may have come across his published, New York Times best-selling book on aging, Lifespan: Why We Age – And Why We Don’t Have To, going deeper into those subjects (you can find our favorite longevity books here). David Sinclair’s main research interest is the epigenetics of aging, with a focus on epigenetic reprogramming of aging (e.g., reversing aging via Yamanaka factors), NAD+ metabolism and sirtuins, and NAD+ precursors like NR and NMN. David Sinclair is a professor at Harvard University who has been studying aging for the better part of his academic career.ĭr.
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